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CAS NO : 70288-86-7

Chemical Name  : 22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b

Molecular Formula : C48H74O14

Molecular Weight  : 875.09276 g/mol

Application : Ivermectin is a broad-spectrum anti-parasite medication. Its used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older. Ivermectin is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).

Therapeutic Segment : Anti-parasite medication , Veterinary Drug 

Regulatory Support : Available

Registered with DCGI ( India ) 


Clinical Use:

Veterinary medicine ivermectin is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage. It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and theAustralian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.[27] Clinical evidence suggests kittens are susceptible to ivermectin toxicity.[28] A 0.01% ivermectin topical preparation for treating ear mites in cats  is available.

Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.

Ivermectin is a broad-spectrum antiparasitic agent, traditionally againstparasitic worms. It is mainly used in humans in the treatment ofonchocerciasis (river blindness), but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis, filariasisand enterobiasis), and some epidermal parasitic skin diseases, includingscabies.

Ivermectin  is currently being used to help eliminate river blindness (onchocerciasis) and to stop transmission of lymphatic filariasis and onchocerciasis around the world. Currently, large amounts of ivermectin are given to fight river blindness in countries unable to afford the drug.[6]The disease is endemic in 30 African countries, six Latin American countries, and Yemen, according to studies conducted by the World Health Organization.[7] The drug rapidly kills microfilariae, but not the adult worms. A single oral dose of ivermectin, taken annually for the 10- to 15-year lifespan of the adult worms, is all that is needed to protect the individual from onchocerciasis.[8]

An Ivermectin cream has been approved by for treatment of rosacea